Novel imidazopyridine suppresses STAT3 activation by targeting SHP-1

• 主要な著者: Jung-Chen Su (著者), Chuan-Hsun Chang (著者), Szu-Hsien Wu (著者), Chung-Wai Shiau (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The unregulated activation of STAT3 has been demonstrated to occur in many cancers and enhances tumour growth, migration, and invasion. Stimulation by cytokines, growth factors, and hormones triggers this activation by phosphorylating STAT3 at tyrosine 705. Novel imidazopyridine compounds were synth...