Histopathological changes and clinical responses of Buruli ulcer plaque lesions during chemotherapy: a role for surgical removal of necrotic tissue?

• Main Authors: Marie-Thérèse Ruf (Author), Ghislain Emmanuel Sopoh (Author), Luc Valère Brun (Author), Ange Dodji Dossou (Author), Yves Thierry Barogui (Author), Roch Christian Johnson (Author), Gerd Pluschke (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Buruli ulcer (BU) caused by Mycobacterium ulcerans is a necrotizing skin disease usually starting with a subcutaneous nodule or plaque, which may ulcerate and progress, if untreated, over months and years. During the currently recommended antibiotic treatment with rifampicin/streptomycin...