A Novel Protocol Using Small-Scale Spray-Drying for the Efficient Screening of Solid Dispersions in Early Drug Development and Formulation, as a Straight Pathway from Screening to Manufacturing Stages

• Váldodahkkit: Aymeric Ousset (Dahkki), Rosanna Chirico (Dahkki), Florent Robin (Dahkki), Martin Alexander Schubert (Dahkki), Pascal Somville (Dahkki), Kalliopi Dodou (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2018-08-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

This work describes a novel screening strategy that implements small-scale spray-drying in early development of binary amorphous solid dispersions (ASDs). The proposed methodology consists of a three-stage decision protocol in which small batches (20–100 mg) of spray-dried solid dispersion...