A novel microbial and hepatic biotransformation-integrated network pharmacology strategy explores the therapeutic mechanisms of bioactive herbal products in neurological diseases: the effects of Astragaloside IV on intracerebral hemorrhage as an example

• Main Authors: En Hu (Author), Zhilin Li (Author), Teng Li (Author), Xueping Yang (Author), Ruoqi Ding (Author), Haoying Jiang (Author), Hong Su (Author), Menghan Cheng (Author), Zhe Yu (Author), Haigang Li (Author), Tao Tang (Author), Yang Wang (Author)
• Format: Book
• Published: BMC, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The oral bioavailability and blood-brain barrier permeability of many herbal products are too low to explain the significant efficacy fully. Gut microbiota and liver can metabolize herbal ingredients to more absorbable forms. The current study aims to evaluate the ability of a no...