Design, synthesis, molecular modelling and antitumor evaluation of S-glucosylated rhodanines through topo II inhibition and DNA intercalation

• Egile Nagusiak: Ahmed I. Khodair (Egilea), Fatimah M. Alzahrani (Egilea), Mohamed K. Awad (Egilea), Siham A. Al-Issa (Egilea), Ghaferah H. Al-Hazmi (Egilea), Mohamed S. Nafie (Egilea)
• Formatua: Liburua
• Argitaratua: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

In the present study, 5-arylidene rhodanine derivatives 3a-f, N-glucosylation rhodanine 6, S-glucosylation rhodanine 7, N-glucoside rhodanine 8 and S-glucosylation 5-arylidene rhodanines 13a-c were synthesised and screened for cytotoxicity against a panel of cancer cells with investigating the effec...