Extrarenal manifestations of complement mediated thrombotic microangiopathies

• Main Authors: Johannes eHofer (Author), Alejandra eRosales (Author), Caroline eFischer (Author), Thomas eGiner (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Thrombotic microangiopathies (TMA) are rare but severe disorders, characterized by endothelial cell activation and thrombus formation leading to hemolytic anemia, thrombocytopenia and organ failure. Complement over activation in combination with defects in its regulation is described in an increasin...