Modulation by Sigma-1 Receptor of Morphine Analgesia and Tolerance: Nociceptive Pain, Tactile Allodynia and Grip Strength Deficits During Joint Inflammation

• Main Authors: Ángeles Montilla-García (Author), Miguel Á. Tejada (Author), M. Carmen Ruiz-Cantero (Author), Inmaculada Bravo-Caparrós (Author), Sandra Yeste (Author), Daniel Zamanillo (Author), Enrique J. Cobos (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sigma-1 receptor antagonism increases the effects of morphine on nociceptive pain, even in morphine-tolerant animals. However, it is unknown whether these receptors are able to modulate morphine antinociception and tolerance during inflammatory pain. Here we used a mouse model to test the modulation...