Modulation by Sigma-1 Receptor of Morphine Analgesia and Tolerance: Nociceptive Pain, Tactile Allodynia and Grip Strength Deficits During Joint Inflammation

• Prif Awduron: Ángeles Montilla-García (Awdur), Miguel Á. Tejada (Awdur), M. Carmen Ruiz-Cantero (Awdur), Inmaculada Bravo-Caparrós (Awdur), Sandra Yeste (Awdur), Daniel Zamanillo (Awdur), Enrique J. Cobos (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Frontiers Media S.A., 2019-02-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Sigma-1 receptor antagonism increases the effects of morphine on nociceptive pain, even in morphine-tolerant animals. However, it is unknown whether these receptors are able to modulate morphine antinociception and tolerance during inflammatory pain. Here we used a mouse model to test the modulation...