Preparation and Preliminary Evaluation of Novel β-Cyclodextrin/IUDR Prodrug Formulations

• Main Authors: Leonard I. Wiebe (Author), Xiao-Hong Yang (Author), Shradha Singh (Author), Jim Diakur (Author)
• Format: Book
• Published: Frontiers Media S.A., 2008-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PURPOSE. Iododeoxyuridine (IUdR) has a very short in vivo half-life and consequently achieves low target-tissue concentrations with concomitant lower efficacy than would be predicted from in vitro studies. This work reports the preparation of IUdR:?-cyclodextrin (?-CyD) inclusion complexes designed...