Preparation and Preliminary Evaluation of Novel β-Cyclodextrin/IUDR Prodrug Formulations

• Principais autores: Leonard I. Wiebe (Autor), Xiao-Hong Yang (Autor), Shradha Singh (Autor), Jim Diakur (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2008-06-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

PURPOSE. Iododeoxyuridine (IUdR) has a very short in vivo half-life and consequently achieves low target-tissue concentrations with concomitant lower efficacy than would be predicted from in vitro studies. This work reports the preparation of IUdR:?-cyclodextrin (?-CyD) inclusion complexes designed...