A novel colchicine-myricetin heterozygous molecule: design, synthesis, and effective evaluations on the pathological models of acute lung injury in vitro and in vivo

• Main Authors: Zhiyue Li (Author), Xueqin Yan (Author), Jiangchun Wei (Author), Liuyang Pu (Author), Guanbao Zhu (Author), Yongkai Cao (Author), Zhanyan Liu (Author), Yaqian Liu (Author), Yan Li (Author), Limin Li (Author), Xinping Li (Author), Zhengzhi Wu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute lung injury (ALI) is an inflammatory condition and there are no effective treatments. A novel new compound----colchicine-myricetin hybrid (CMyrH) was herein designed and synthesized. To evaluate the activity of CMyrH in ALI, we used a bleomycin (BLM) induced BEAS-2B injury model in vitro and e...