Conserved properties of genetic architecture of renal and fat transcriptomes in rat models of insulin resistance

• Main Authors: Georg W. Otto (Author), Pamela J. Kaisaki (Author), Francois Brial (Author), Aurélie Le Lay (Author), Jean-Baptiste Cazier (Author), Richard Mott (Author), Dominique Gauguier (Author)
• Format: Book
• Published: The Company of Biologists, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To define renal molecular mechanisms that are affected by permanent hyperglycaemia and might promote phenotypes relevant to diabetic nephropathy, we carried out linkage analysis of genome-wide gene transcription in the kidneys of F2 offspring from the Goto-Kakizaki (GK) rat model of type 2 diabetes...