Discovery of a non-peptidic inhibitor of west nile virus NS3 protease by high-throughput docking.

Discovery of a non-peptidic inhibitor of west nile virus NS3 protease by high-throughput docking.

BACKGROUND: The non-structural 3 protease (NS3pro) is an essential flaviviral enzyme and therefore one of the most promising targets for drug development against West Nile virus (WNV) and dengue infections. METHODOLOGY: In this work, a small-molecule inhibitor of the WNV NS3pro has been identified b...

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Main Authors: Dariusz Ekonomiuk (Author), Xun-Cheng Su (Author), Kiyoshi Ozawa (Author), Christophe Bodenreider (Author), Siew Pheng Lim (Author), Zheng Yin (Author), Thomas H Keller (Author), David Beer (Author), Viral Patel (Author), Gottfried Otting (Author), Amedeo Caflisch (Author), Danzhi Huang (Author)
Format: Book
Published: Public Library of Science (PLoS), 2009-01-01T00:00:00Z.
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