Fabrication and Appraisal of Simvastatin via Tailored Niosomal Nanovesicles for Transdermal Delivery Enhancement: In Vitro and In Vivo Assessment

• Auteurs principaux: Heba F. Salem (Auteur), Rasha M. Kharshoum (Auteur), Heba A. Abou-Taleb (Auteur), Hanan Osman Farouk (Auteur), Randa Mohammed Zaki (Auteur)
• Format: Livre
• Publié: MDPI AG, 2021-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Simvastatin (SIM) is a HMG-CoA reductase inhibitor employed in the management of hyperlipidemia. However, its low bioavailability limits its clinical efficacy. The objective of this study was to overcome the poor bioavailability of SIM via the transdermal application of a SIM-loaded niosomal gel. Ni...