N-terminal transactivation function, AF-1, of estrogen receptor alpha controls obesity through enhancement of energy expenditure

• Main Authors: Yukitomo Arao (Author), Katherine J. Hamilton (Author), Sydney L. Lierz (Author), Kenneth S. Korach (Author)
• Format: Knjiga
• Izdano: Elsevier, 2018-12-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Objective: Studies using the estrogen receptor alpha (ERα) knock-out (αERKO) mice have demonstrated that ERα plays a crucial role in various estrogen-mediated metabolic regulations. ERα is a ligand dependent transcription regulator and its activity is regulated by estrogenic compounds. ERα consists...