Hypoxia-induced NLRP3 inflammasome activation via the HIF-1α/NF-κB signaling pathway in human dental pulp fibroblasts

• Main Authors: Diya Wang (Author), Minghao Wang (Author), Shukai Sun (Author), Chongyang Zhang (Author), Ya Song (Author), Jianing Li (Author), Bing Song (Author), Haipeng Lv (Author), Shengchao Wang (Author), Wenkai Jiang (Author)
• Format: Book
• Published: BMC, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Previous studies have reported the link between hypoxic conditions and NLRP3 inflammasome-mediated pulpal inflammation in the progression of pulpitis. However, the underlying mechanism has not been fully elucidated. This study aimed to investigate the role of HIF-1α in the regula...