Symmetric molecules with 1,4-triazole moieties as potent inhibitors of tumour-associated lactate dehydrogenase-A

• Hauptverfasser: Abdul-Malek S. Altamimi (Verfasst von), Ahmed M. Alafeefy (Verfasst von), Agnese Balode (Verfasst von), Igor Vozny (Verfasst von), Aleksandrs Pustenko (Verfasst von), Mohey Eldin El Shikh (Verfasst von), Fatmah A. S. Alasmary (Verfasst von), Sherif A. Abdel-Gawad (Verfasst von), Raivis Žalubovskis (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

A series of symmetric molecules incorporating aryl or pyridyl moieties as central core and 1,4-substituted triazoles as a side bridge was synthesised. The new compounds were investigated as lactate dehydro-genase (LDH, EC 1.1.1.27) inhibitors. The cancer associated LDHA isoform was inhibited with IC...