Symmetric molecules with 1,4-triazole moieties as potent inhibitors of tumour-associated lactate dehydrogenase-A

• Main Authors: Abdul-Malek S. Altamimi (Author), Ahmed M. Alafeefy (Author), Agnese Balode (Author), Igor Vozny (Author), Aleksandrs Pustenko (Author), Mohey Eldin El Shikh (Author), Fatmah A. S. Alasmary (Author), Sherif A. Abdel-Gawad (Author), Raivis Žalubovskis (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of symmetric molecules incorporating aryl or pyridyl moieties as central core and 1,4-substituted triazoles as a side bridge was synthesised. The new compounds were investigated as lactate dehydro-genase (LDH, EC 1.1.1.27) inhibitors. The cancer associated LDHA isoform was inhibited with IC...