Targeted Ablation of Primary Cilia in Differentiated Dopaminergic Neurons Reduces Striatal Dopamine and Responsiveness to Metabolic Stress

Targeted Ablation of Primary Cilia in Differentiated Dopaminergic Neurons Reduces Striatal Dopamine and Responsiveness to Metabolic Stress

Primary cilia (PC) are microtubule-based protrusions of the cell membrane transducing molecular signals during brain development. Here, we report that PC are required for maintenance of Substantia nigra (SN) dopaminergic (DA) neurons highly vulnerable in Parkinson's disease (PD). Targeted block...

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Main Authors: Rasem Mustafa (Author), Chahinaz Rawas (Author), Nadja Mannal (Author), Grzegorz Kreiner (Author), Björn Spittau (Author), Katarzyna Kamińska (Author), Rüstem Yilmaz (Author), Christina Pötschke (Author), Joachim Kirsch (Author), Birgit Liss (Author), Kerry L. Tucker (Author), Rosanna Parlato (Author)
Format: Book
Published: MDPI AG, 2021-08-01T00:00:00Z.
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3rd Floor Main Library

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