Targeted Ablation of Primary Cilia in Differentiated Dopaminergic Neurons Reduces Striatal Dopamine and Responsiveness to Metabolic Stress

• Main Authors: Rasem Mustafa (Author), Chahinaz Rawas (Author), Nadja Mannal (Author), Grzegorz Kreiner (Author), Björn Spittau (Author), Katarzyna Kamińska (Author), Rüstem Yilmaz (Author), Christina Pötschke (Author), Joachim Kirsch (Author), Birgit Liss (Author), Kerry L. Tucker (Author), Rosanna Parlato (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2021-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Primary cilia (PC) are microtubule-based protrusions of the cell membrane transducing molecular signals during brain development. Here, we report that PC are required for maintenance of Substantia nigra (SN) dopaminergic (DA) neurons highly vulnerable in Parkinson's disease (PD). Targeted block...