The Dual Dose-Dependent Effects of Corticosterone on Hippocampal Cell Apoptosis After Traumatic Brain Injury Depend on the Activation Ratio of Mineralocorticoid Receptors to Glucocorticoid Receptors

• Main Authors: Bin Zhang (Author), Mengshi Yang (Author), Qiongyu Yan (Author), Xiaojian Xu (Author), Fei Niu (Author), Jinqian Dong (Author), Yuan Zhuang (Author), Shenghua Lu (Author), Qianqian Ge (Author), Baiyun Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In our recent studies, we reported that mineralocorticoid receptor (MR) had the opposite effects of glucocorticoid receptor (GR) on neural cell survival after traumatic brain injury (TBI). However, whether short-term use of high-dose natural glucocorticoids, which are mixed agonists of both MR and G...