Absence of Interactive Effects of trans-1,2-Cyclohexanediol, a Major Metabolite of the Side-Chain of Candesartan Cilexetil, on Digoxin-Induced Arrhythmias in Dogs

• Main Authors: Keiji Yamamoto (Author), Takahito Kitayoshi (Author), Satoshi Nishimura (Author), Fumio Chatani (Author), Toshifumi Watanabe (Author)
• Format: Book
• Published: Elsevier, 2003-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

trans-1,2-Cyclohexanediol, the major metabolite of the cilexetil moiety of candesartan cilexetil (CC), has been reported to have potent pro-arrhythmic effects in dogs with congestive heart failure (CHF), especially when co-administered with digoxin. To verify this and to clarify the clinical relevan...