Hydrogen Sulfide Causes Relaxation in Mouse Bronchial Smooth Muscle
We investigated the effects of NaHS, a hydrogen sulfide (H2S) donor, on the tension of isolated mouse and guinea-pig bronchial rings. NaHS at 0.01 - 10 mM had no effect on the tone of those preparations without precontraction. When the preparation was precontracted with carbachol, NaHS at 0.1 - 3 mM...
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| Main Authors: | , , , |
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| Format: | Book |
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Elsevier,
2007-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | We investigated the effects of NaHS, a hydrogen sulfide (H2S) donor, on the tension of isolated mouse and guinea-pig bronchial rings. NaHS at 0.01 - 10 mM had no effect on the tone of those preparations without precontraction. When the preparation was precontracted with carbachol, NaHS at 0.1 - 3 mM strongly relaxed the mouse rings, but produced only slight relaxation in the guinea-pig rings. The NaHS-induced relaxation in the mouse bronchus was resistant to inhibitors of ATP-sensitive K+ channels, soluble guanylyl cyclase, cyclooxygenase (COX)-1 or COX-2, and antagonists of tachykinin receptors. Thus, NaHS evokes bronchodilation in mice, suggesting a possible role for H2S in the respiratory system. Keywords:: hydrogen sulfide (H2S), smooth muscle, bronchodilation |
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| Item Description: | 1347-8613 10.1254/jphs.SC0070199 |