Effect of ITPA Polymorphism on Adverse Drug Reactions of 6-Mercaptopurine in Pediatric Patients with Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis

• Main Authors: Yeonhong Lee (Author), Eun Jeong Jang (Author), Ha-Young Yoon (Author), Jeong Yee (Author), Hye-Sun Gwak (Author)
• Format: Knjiga
• Izdano: MDPI AG, 2022-03-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

6-Mercaptopurine (6-MP) is a cornerstone of the maintenance regimen for pediatric acute lymphoblastic leukemia (ALL). Inosine triphosphate pyrophosphatase (ITPA) is considered a candidate pharmacogenetic marker that may affect metabolism and 6-MP-induced toxicities; however, the findings are inconsi...