Anesthesia promotes acute expression of genes related to Alzheimer's disease and latent tau aggregation in transgenic mouse models of tauopathy

• Main Authors: John David Eun (Author), Heidy Jimenez (Author), Leslie Adrien (Author), Adam Wolin (Author), Philippe Marambaud (Author), Peter Davies (Author), Jeremy L. Koppel (Author)
• Format: Book
• Published: BMC, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Exposure to anesthesia in the elderly might increase the risk of dementia. Although the mechanism underlying the association is uncertain, anesthesia has been shown to induce acute tau hyperphosphorylation in preclinical models. We sought to investigate the impact of anesthesia o...