Developmental abnormalities in supporting cell phalangeal processes and cytoskeleton in the Gjb2 knockdown mouse model

• Main Authors: Sen Chen (Author), Le Xie (Author), Kai Xu (Author), Hai-Yan Cao (Author), Xia Wu (Author), Xiao-Xiang Xu (Author), Yu Sun (Author), Wei-Jia Kong (Author)
• Format: Book
• Published: The Company of Biologists, 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mutations in the GJB2 gene [which encodes connexin 26 (Cx26)] are the most common causes of hereditary hearing loss in humans, and previous studies showed postnatal development arrest of the organ of Corti in different Cx26-null mouse models. To explore the pathological changes and the mechanism beh...