Preclinical Pharmacokinetics of MI-219, a Novel Human Double Minute 2 (HDM2) Inhibitor and Prediction of Human Pharmacokinetics

• Main Authors: Peng Zou (Author), Nan Zheng (Author), Yanke Yu (Author), Shanghai Yu (Author), Wei Sun (Author), Donna McEachem (Author), Yongsheng Yang (Author), Lawrence X Yu (Author), Shaomeg Wang (Author), Duxin Sun (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose. The two purposes of this study were evaluating preclinical pharmacokinetics of MI-219 and predicting clearance (CL) and volume of distribution at steady-state (Vdss) of MI-219 in humans. Methods. Pharmacokinetic studies were conducted on mice, rats, dogs, and monkeys. Human CL of MI-219 was...