Predicted expression of genes involved in the thiopurine metabolic pathway and azathioprine discontinuation due to myelotoxicity

• Main Authors: Laura L. Daniel (Author), Alyson L. Dickson (Author), Jacy T. Zanussi (Author), Tyne W. Miller‐Fleming (Author), Peter S. Straub (Author), Wei‐Qi Wei (Author), W. Dale Plummer (Author), William D. Dupont (Author), Ge Liu (Author), Prathima Anandi (Author), Tyler S. Reese (Author), Kelly A. Birdwell (Author), Vivian K. Kawai (Author), Adriana M. Hung (Author), Nancy J. Cox (Author), QiPing Feng (Author), C. Michael Stein (Author), Cecilia P. Chung (Author)
• Format: Book
• Published: Wiley, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract TPMT and NUDT15 variants explain less than 25% of azathioprine‐associated myelotoxicity. There are 25 additional genes in the thiopurine pathway that could also contribute to azathioprine myelotoxicity. We hypothesized that among TPMT and NUDT15 normal metabolizers, a score combining the ge...