Viperin is induced following dengue virus type-2 (DENV-2) infection and has anti-viral actions requiring the C-terminal end of viperin.

• Main Authors: Karla J Helbig (Author), Jillian M Carr (Author), Julie K Calvert (Author), Satiya Wati (Author), Jennifer N Clarke (Author), Nicholas S Eyre (Author), Sumudu K Narayana (Author), Guillaume N Fiches (Author), Erin M McCartney (Author), Michael R Beard (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The host protein viperin is an interferon stimulated gene (ISG) that is up-regulated during a number of viral infections. In this study we have shown that dengue virus type-2 (DENV-2) infection significantly induced viperin, co-incident with production of viral RNA and via a mechanism requiring reti...