Active immunoprophylaxis with a synthetic DNA-encoded monoclonal anti-respiratory syncytial virus scFv-Fc fusion protein confers protection against infection and durable activity

• Main Authors: Katherine Schultheis (Author), Holly M Pugh (Author), Janet Oh (Author), Jacklyn Nguyen (Author), Bryan Yung (Author), Charles Reed (Author), Neil Cooch (Author), Jing Chen (Author), Jian Yan (Author), Kar Muthumani (Author), Laurent M. Humeau (Author), David B. Weiner (Author), Kate E. Broderick (Author), Trevor R. F. Smith (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Respiratory Syncytial virus (RSV) is a major threat to many vulnerable populations. There are currently no approved vaccines, and RSV remains a high unmet global medical need. Here we describe the employment of a novel synthetic DNA-encoded antibody technology platform to develop and deliver an engi...