Carbonic Anhydrase IX-Targeted α-Radionuclide Therapy with 225Ac Inhibits Tumor Growth in a Renal Cell Carcinoma Model

• Main Authors: Robin I. J. Merkx (Author), Mark Rijpkema (Author), Gerben M. Franssen (Author), Annemarie Kip (Author), Bart Smeets (Author), Alfred Morgenstern (Author), Frank Bruchertseifer (Author), Eddie Yan (Author), Michael P. Wheatcroft (Author), Egbert Oosterwijk (Author), Peter F. A. Mulders (Author), Sandra Heskamp (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we compared the tumor-targeting properties, therapeutic efficacy, and tolerability of the humanized anti-CAIX antibody (hG250) labeled with either the α-emitter actinium-225 (²²⁵Ac) or the β^--emitter lutetium-177 (¹⁷⁷...