Complete Cocrystal Formation during Resonant Acoustic Wet Granulation: Effect of Granulation Liquids

• Main Authors: Ryoma Tanaka (Author), Supisara Osotprasit (Author), Jomjai Peerapattana (Author), Kazuhide Ashizawa (Author), Yusuke Hattori (Author), Makoto Otsuka (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The manufacturing of solid pharmaceutical dosage forms composed of cocrystals requires numerous processes during which there is risk of dissociation into parent molecules. Resonant acoustic wet granulation (RAG) was devised in an effort to complete theophylline-citric acid (THPCIT) cocrystal formati...