Investigation of simplified physiologically‐based pharmacokinetic models in rat and human

• Hauptverfasser: Estelle Yau (Verfasst von), Andrés Olivares‐Morales (Verfasst von), Kayode Ogungbenro (Verfasst von), Leon Aarons (Verfasst von), Michael Gertz (Verfasst von)
• Format: Buch
• Veröffentlicht: Wiley, 2023-03-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Whole‐body physiologically‐based pharmacokinetic (PBPK) models have many applications in drug research and development. It is often necessary to inform these models with animal or clinical data, updating model parameters, and making the model more predictive for future applications. This pr...