Investigation of simplified physiologically‐based pharmacokinetic models in rat and human

• Autori principali: Estelle Yau (Autore), Andrés Olivares‐Morales (Autore), Kayode Ogungbenro (Autore), Leon Aarons (Autore), Michael Gertz (Autore)
• Natura: Libro
• Pubblicazione: Wiley, 2023-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Whole‐body physiologically‐based pharmacokinetic (PBPK) models have many applications in drug research and development. It is often necessary to inform these models with animal or clinical data, updating model parameters, and making the model more predictive for future applications. This pr...