Distinct genetic signals at the FGF21 locus complicate studies of FGF21's role in diet regulation using human cohort data

• Main Authors: Stina Ramne (Author), Mario García-Ureña (Author), Matthew P. Gillum (Author), Lars Ängquist (Author), Torben Hansen (Author), Jordi Merino (Author), Niels Grarup (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Experimental and genetic studies suggest that fibroblast growth factor 21 (FGF21) modulates macronutrient and alcohol preferences, but evidence of such regulation in humans remains scarce. To address this gap in translation, we aimed to map the relationships between plasma FGF21 levels,...