A combined physiologically‐based pharmacokinetic and quantitative systems pharmacology model for modeling amyloid aggregation in Alzheimer's disease

• Main Authors: Hugo Geerts (Author), Mike Walker (Author), Rachel Rose (Author), Silke Bergeler (Author), Piet H. van derGraaf (Author), Edgar Schuck (Author), Akihiko Koyama (Author), Sanae Yasuda (Author), Ziad Hussein (Author), Larisa Reyderman (Author), Chad Swanson (Author), Antonio Cabal (Author)
• Format: Book
• Published: Wiley, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Antibody‐mediated removal of aggregated β‐amyloid (Aβ) is the current, most clinically advanced potential disease‐modifying treatment approach for Alzheimer's disease. We describe a quantitative systems pharmacology (QSP) approach of the dynamics of Aβ monomers, oligomers, protofibrils...