Current strategies for the targeted treatment of high-grade serous epithelial ovarian cancer and relevance of BRCA mutational status

• Main Authors: Angiolo Gadducci (Author), Valentina Guarneri (Author), Fedro Alessandro Peccatori (Author), Graziana Ronzino (Author), Giuseppa Scandurra (Author), Claudio Zamagni (Author), Paolo Zola (Author), Vanda Salutari (Author)
• Format: Book
• Published: BMC, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Epithelial ovarian cancer is the most lethal gynecologic malignancy. In most women, it is diagnosed at an advanced stage, which largely explains the poor prognosis of this malignancy. Germline mutations of the genes BRCA1 and BRCA2, which encode proteins essential for the repair of double-s...