Dexmedetomidine alleviates inflammatory response and oxidative stress injury of vascular smooth muscle cell via α2AR/GSK-3β/MKP-1/NRF2 axis in intracranial aneurysm

Abstract Vascular smooth muscle cell (VSMC) phenotypic modulation regulates the initiation and progression of intracranial aneurysm (IA). Dexmedetomidine (DEX) is suggested to play neuroprotective roles in patients with craniocerebral injury. Therefore, we investigated the biological functions of DE...

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Main Authors: Ze Zhang (Author), Xiue Mu (Author), Xiaohui Zhou (Author)
Format: Book
Published: BMC, 2022-10-01T00:00:00Z.
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3rd Floor Main Library

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