Identification of Cysteine-Rich Epidermal Growth Factor-Like Domain 1α (CRELD1α) as a Novel α1A-Adrenoceptor-Down-Regulating Protein and Establishment of an α1L-Adrenoceptor-Expressing Cell Line

• Main Authors: Atsushi Nishimune (Author), Fumiko Suzuki (Author), Hatsumi Yoshiki (Author), Shigeru Morishima (Author), Ikunobu Muramatsu (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Two distinct α1-adrenoceptor phenotypes (α1A- and α1L-ARs) are known to originate from a single ADRA1A(α1a) gene by an as-yet-unknown mechanism. We hypothesized that an α1a-AR-interacting protein could generate the α1L-AR phenotype and we sought to identify such a protein and to examine its effects...