Identification of Cysteine-Rich Epidermal Growth Factor-Like Domain 1α (CRELD1α) as a Novel α1A-Adrenoceptor-Down-Regulating Protein and Establishment of an α1L-Adrenoceptor-Expressing Cell Line

• Hauptverfasser: Atsushi Nishimune (Verfasst von), Fumiko Suzuki (Verfasst von), Hatsumi Yoshiki (Verfasst von), Shigeru Morishima (Verfasst von), Ikunobu Muramatsu (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2010-01-01T00:00:00Z.
• Schlagworte: article
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Two distinct α1-adrenoceptor phenotypes (α1A- and α1L-ARs) are known to originate from a single ADRA1A(α1a) gene by an as-yet-unknown mechanism. We hypothesized that an α1a-AR-interacting protein could generate the α1L-AR phenotype and we sought to identify such a protein and to examine its effects...