Pulmonary Metabolism of Substrates for Key Drug-Metabolizing Enzymes by Human Alveolar Type II Cells, Human and Rat Lung Microsomes, and the Isolated Perfused Rat Lung Model

• Hauptverfasser: Katarina Rubin (Verfasst von), Pär Ewing (Verfasst von), Erica Bäckström (Verfasst von), Anna Abrahamsson (Verfasst von), Britta Bonn (Verfasst von), Satoshi Kamata (Verfasst von), Ken Grime (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2020-02-01T00:00:00Z.
• Schlagworte: article
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Significant pulmonary metabolism of inhaled drugs could have drug safety implications or influence pharmacological effectiveness. To study this in vitro, lung microsomes or S9 are often employed. Here, we have determined if rat and human lung microsomes are fit for purpose or whether it is better to...