High-affinity RNA Aptamers Against the HIV-1 Protease Inhibit Both In Vitro Protease Activity and Late Events of Viral Replication

• Autors principals: Sonald Duclair (Autor), Archana Gautam (Autor), Andrew Ellington (Autor), Vinayaka R Prasad (Autor)
• Format: Llibre
• Publicat: Elsevier, 2015-01-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

HIV-1 aspartyl protease (PR) plays a key role in virion morphogenesis, underscoring the effectiveness of protease inhibitors (PI). Despite their utility, side effects and drug-resistance remains a problem. We report the development of RNA aptamers as inhibitors of HIV-1 PR for potential use in anti-...