Isoalantolactone Induces Cell Cycle Arrest, Apoptosis and Autophagy in Colorectal Cancer Cells

• Main Authors: Junkui Li (Author), Peili Zhu (Author), Yifei Chen (Author), Shiqing Zhang (Author), Zhu Zhang (Author), Zhang Zhang (Author), Ying Wang (Author), Xiaoli Jiang (Author), Kaili Lin (Author), Wei Wu (Author), Zhixian Mo (Author), Stephen Cho Wing Sze (Author), Ken Kin Lam Yung (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Colorectal cancer (CRC) is an aggressive cancer. Isoalantolactone (IATL) has been reported to exert cytotoxicity against various cancer cells, but not CRC. In this study, we explored the anti-CRC effects and mechanism of action of IATL in vitro and in vivo. Our results demonstrated that IATL inhibit...