Iron overload and impaired iron handling contribute to the dystrophic pathology in models of Duchenne muscular dystrophy

• Main Authors: Francesca M. Alves (Author), Kai Kysenius (Author), Marissa K. Caldow (Author), Justin P. Hardee (Author), Jin D. Chung (Author), Jennifer Trieu (Author), Dominic J. Hare (Author), Peter J. Crouch (Author), Scott Ayton (Author), Ashley I. Bush (Author), Gordon S. Lynch (Author), René Koopman (Author)
• Format: Book
• Published: Wiley, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Oxidative stress is implicated in the pathophysiology of Duchenne muscular dystrophy (DMD, caused by mutations in the dystrophin gene), which is the most common and severe of the muscular dystrophies. To our knowledge, the distribution of iron, an important modulator of oxidative...