Carboranyl-1,8-naphthalimide intercalators induce lysosomal membrane permeabilization and ferroptosis in cancer cell lines

• Main Authors: Sebastian Rykowski (Author), Dorota Gurda-Woźna (Author), Agnieszka Fedoruk-Wyszomirska (Author), Marta Orlicka-Płocka (Author), Aleksandra Kowalczyk (Author), Paweł Stączek (Author), Marta Denel-Bobrowska (Author), Katarzyna Biniek-Antosiak (Author), Wojciech Rypniewski (Author), Eliza Wyszko (Author), Agnieszka B. Olejniczak (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The synthesis of carborane-1,8-naphthalimide conjugates and evaluation of their DNA-binding ability and anticancer activity were performed. A series of 4-carboranyl-3-nitro-1,8-naphthalimide derivatives, mitonafide and pinafide analogs, were synthesised via amidation and reductive amination reaction...