Use of Exposure Data to Establish Causality in Drug-Adverse Event Relationships: An Example with Desvenlafaxine

• Main Authors: Andrea Rodríguez-Lopez (Author), Gina Mejía-Abril (Author), Pablo Zubiaur (Author), Sofía Calleja (Author), Manuel Román (Author), Francisco Abad-Santos (Author), Dolores Ochoa (Author)
• Format: Book
• Published: MDPI AG, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Causality algorithms help establish relationships between drug use and adverse event (AE) occurrence. High drug exposure leads to a higher likelihood of an AE being classified as an adverse drug reaction (ADR). However, there is a knowledge gap regarding what concentrations are predictive of ADRs, a...