Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein.

• Main Authors: Yadunanda Budigi (Author), Eugenia Z Ong (Author), Luke N Robinson (Author), Li Ching Ong (Author), Kirk J Rowley (Author), Alexander Winnett (Author), Hwee Cheng Tan (Author), Sven Hobbie (Author), Zachary Shriver (Author), Gregory J Babcock (Author), Sylvie Alonso (Author), Eng Eong Ooi (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dengue virus (DENV) infection imposes enormous health and economic burden worldwide with no approved treatment. Several small molecules, including lovastatin, celgosivir, balapiravir and chloroquine have been tested for potential anti-dengue activity in clinical trials; none of these have demonstrat...