Effects of experimental conditions on solubility measurements for BCS classification in order to improve the biowaiver guidelines

• Main Authors: Patrícia Fernanda Monteiro (Author), Neila Márcia Silva-Barcellos (Author), Tamires Guedes Caldeira (Author), Adriana Cotta Cardoso Reis (Author), Amanda Santos Ribeiro (Author), Jacqueline de Souza (Author)
• Format: Book
• Published: Universidade de São Paulo, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Among the methods described for determining the solubility, shake-flask is suitable to evaluate the equilibrium solubility according to the BCS. Nevertheless, experimental conditions related to the shake-flask method are not well described. Evaluating the effects of experimental conditions on solubi...