Regulation of Hepatic UGT2B15 by Methylation in Adults of Asian Descent

• প্রধান লেখক: Steffen G. Oeser (Author), Jon-Paul Bingham (Author), Abby C. Collier (Author)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2018-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

The hepatic uridine 5'-diphosphate-glucuronosyl transferases (UGTs) are critical for detoxifying endo- and xenobiotics. Since UGTs are also dynamically responsive to endogenous and exogenous stimuli, we examined whether epigenetic DNA methylation can regulate hepatic UGT expression and differen...