Inhibition of Clostridioides difficile Toxins TcdA and TcdB by Ambroxol

• Main Authors: Sebastian Heber (Author), Lara Barthold (Author), Jan Baier (Author), Panagiotis Papatheodorou (Author), Giorgio Fois (Author), Manfred Frick (Author), Holger Barth (Author), Stephan Fischer (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clostridioides (C.) difficile produces the exotoxins TcdA and TcdB, which are the predominant virulence factors causing C. difficile associated disease (CDAD). TcdA and TcdB bind to target cells and are internalized via receptor-mediated endocytosis. Translocation of the toxins' enzyme subunits...