Rapidly boosted Plasma IL-5 induced by treatment of human Schistosomiasis haematobium is dependent on antigen dose, IgE and eosinophils.

• Main Authors: Shona Wilson (Author), Frances M Jones (Author), Hassan K M Fofana (Author), Aissata Doucouré (Author), Aly Landouré (Author), Gachuhi Kimani (Author), Joseph K Mwatha (Author), Moussa Sacko (Author), Birgitte J Vennervald (Author), David W Dunne (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IgE specific to worm antigen (SWA) and pre-treatment eosinophil number, are associated with human immunity to re-infection with schistosomes after chemotherapeutic treatment. Treatment significantly elevates circulating IL-5 24-hr post-treatment of Schistosoma mansoni. Here we investigate if praziqu...