Lactobacillus rhamnosus GG ameliorates triptolide-induced liver injury through modulation of the bile acid-FXR axis

• Main Authors: Shiping Hu (Author), Bo Tang (Author), Cheng Lu (Author), Sumin Wang (Author), Lingyi Wu (Author), Yuanyuan Lei (Author), Li Tang (Author), Hongbin Zhu (Author), Dongxu Wang (Author), Shiming Yang (Author)
• Format: Book
• Published: Elsevier, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triptolide (TP) is the principal bioactive compound of Tripterygium wilfordii with significant anti-tumor, anti-inflammatory and immunosuppressive activities. However, its severe hepatotoxicity greatly limits its clinical use. The underlying mechanism of TP-induced liver damage is still poorly under...