Ameliorative effects of tannic acid on carbon tetrachloride-induced liver fibrosis in vivo and in vitro

• Main Authors: Xi Chu (Author), Hua Wang (Author), Yan-min Jiang (Author), Yuan-yuan Zhang (Author), Yi-fan Bao (Author), Xuan Zhang (Author), Jian-ping Zhang (Author), Hui Guo (Author), Fan Yang (Author), Yan-chao Luan (Author), Yong-sheng Dong (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the ameliorative effects and potential mechanisms of tannic acid (TA) in carbon tetrachloride (CCl4)-intoxicated mice and hepatic stellate cells (HSCs). Liver fibrosis was observed in CCl4 (800 ml/kg)-induced mice, and high viability was observed in CCl4 (10 mM)-intoxicated HSCs. Pre...