Pharmacokinetic Evaluation of Eltrombopag in ITP Pediatric Patients

• Main Authors: Marco Dionisi (Author), Sara Cairoli (Author), Raffaele Simeoli (Author), Francesca De Gennaro (Author), Valeria Paganelli (Author), Roberto Carta (Author), Francesca Rossi (Author), Carlo Dionisi-Vici (Author), Giuseppe Palumbo (Author), Bianca Maria Goffredo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Eltrombopag (EPAG) is an oral thrombopoietin receptor agonist, approved for refractory primary immune thrombocytopenia (ITP) in pediatric patients. In two pediatric RCTs, EPAG led to an improvement of platelet counts and a reduction in bleeding severity. However, a significant number of...