Scutellarin inhibits caspase-11 activation and pyroptosis in macrophages via regulating PKA signaling

• Main Authors: Jiezhou Ye (Author), Bo Zeng (Author), Meiyan Zhong (Author), Hongchun Li (Author), Lihui Xu (Author), Junxiang Shu (Author), Yaofeng Wang (Author), Fan Yang (Author), Chunsu Zhong (Author), Xunjia Ye (Author), Xianhui He (Author), Dongyun Ouyang (Author)
• Format: Book
• Published: Elsevier, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inflammatory caspase-11 senses and is activated by intracellular lipopolysaccharide (LPS) leading to pyroptosis that has critical role in defensing against bacterial infection, whereas its excess activation under pathogenic circumstances may cause various inflammatory diseases. However, there are fe...